Participation was supported by the Doctoral School of Clinical Medicine, funded by the Regional Fund of the European Union (Tartu University’s ASTRA project PER ASPERA) and the ERA Chair of Translational Genomics at the University of Tartu (European Union’s Horizon 2020 research and innovation programme under grant agreement No 668989). the ERA Chair of Translational Genomics at the University of Tartu (European Union’s Horizon 2020 research and innovation programme under grant agreement No 668989)